B Cell-T Cell Collaboration: Regulation and Dysregulation

Beginn: Uhr
Ende: Uhr
Schloss Herrenhausen
Fachpublikum Wissenschaft

The Keystone Symposia conference brings together scientists of life sciences to discuss collaboration of B Cells and T Cells on April 4-6, 2022, in Hanover.

B cell-T cell collaboration leads, via the germinal center reaction, to the generation of B cell memory and long-lived affinity-matured protective antibodies. This key immune response has been extensively studied, and, as a result, we have an increasingly refined understanding of the ligands, receptors, and intra-cellular pathways that are involved.

However, many aspects of this remarkable process as it plays out in infections, vaccine responses, and chronic immunological diseases remain unknown. In particular, we still do not understand how B cells integrate complex antigenic and co-stimulatory inputs over time to make critical cell fate decisions, including the process of clonal selection in the germinal center as well as memory B cell and long-lived plasma cell differentiation. We do not fully appreciate the spectrum of ‘non-canonical’ B cell responses to various chronic and acute infections, especially those occurring in tissues rather than secondary lymphoid organs. And finally, many unanswered questions remain about normal and abnormal B cell responses to commensal flora, allergic antigens, and self-antigens that are essential to address if we hope to understand dysregulated B cell immune responses in inflammatory, allergic, and autoimmune disease.

This meeting brings together scientists focused on both the B cell and the Tfh cell contributions to humoral immunity in order to share innovative research focused on addressing this broad set of questions. We aim to identify areas of future investigation, foster collaboration, and collectively generate the knowledge base required to design better vaccines and more precise strategies to treat diseases of immune dysregulation.

Keystone Symposia Conference "B Cell-T Cell Collaboration: Regulation and Dysregulation"
April 4-6, 2022
Herrenhausen Palace, Hanover, Germany


A detailed program can be found at the conference website.


The conference is jointly organized by Keystone Symposia and the Volkswagen Foundation. The Scientific Organizers are Victor L.J. Tybulewicz (Francis Crick Institute, UK), Kai-Michael Toellner (University of Birmingham, UK), Julie Zikherman (University of California, San Francisco, USA) and Pamela L. Schwartzberg (National Institutes of Health, USA).

Keystone Symposia on Molecular and Cellular Biology is a 501(c)(3) nonprofit organization headquartered in Silverthorne, Colorado, USA that convenes open, peer-reviewed conferences across a broad range of the life sciences. The mission of Keystone Symposia is to serve as a catalyst for the advancement of biomedical and life sciences by connecting scientists within and across disciplines at conferences and workshops held at venues that create an environment conducive to information exchange, generation of new ideas and acceleration of applications that benefit society. Approximately 50-60 conferences take place each year.


If you want to attend the conference please register through Keystone Symposia's website.


The conference language is English.

Venue and Public Transport

The conference is held at Herrenhausen Palace, a modern conference center in Hanover, Germany. You can reach the venue by tram: Take line 4 or 5 and get off at "Herrenhäuser Gärten".